Modelling and Simulation of Biological Systems with UG4
Gabriel Wittum, G-CSC, University of Frankfurt
Biological systems are distinguished by their enormous complexity and variability. That is why mathematical modelling and computational simulation of those systems is very difficult, in particular thinking of detailed models which are based on first principles. The difficulties start with geometric modelling which needs to extract basic structures from highly complex and variable phenotypes, on the other hand also has to take the statistic variability into account. Moreover, the models of the processes running on these geometries are not yet well established, since these are equally complex and often couple many scales in space and time. Thus, simulating such systems always means to put the whole frame to test, from modelling to the numerical methods and software tools used for simulation. These need to be advanced in connection with validating simulation results by comparing them to experiments.
To treat problems of this complexity, novel mathematical models, methods and software tools are necessary . In recent years, such models, numerical methods and tools have been developed, allowing to attack these problems. One of these tools is the brandnew simulation system UG4. In the talk, we show several application examples from biology, in particular modeling the barrier property of human skin and the signal processing in neurons.
25.09.2012 at 17:30